Osteoporosis Drug Speeds Fracture Healing

Dr Susan V. Bukata and her collegues at the University of Rochester recently reported encouraging findings on the use of an osteoporosis drug to treat slow healing bone fractures. The team of researchers gave teriparatide to 145 individuals with slow healing or non-healing bone fractures and found that 93% of the individuals healed with an associated decrease in pain after 8-12 weeks. Many of the patients in the study had fractures that had not healed in over 6 months.

Forteo is a synthetic form of parathyroid hormone. Forteo stimulates the cells in the body that build bone and this increases bone mineral density and strengthens bone. Forteo can build bone faster and to a greater degree than the bisphosphonates (such as: Boniva and Fosamax). Teriparatide (Forteo) was approved by the FDA in 2002 for treatment of osteoporosis, but it has not been used as a first line treatment for osteoporosis due to it’s expense. The FDA also requires a black box warning on Forteo because teriparatide caused bone cancer in animal studies. It’s important to note that in the study, twice the human dose of teriparatide was given to rats over a significant portion of their lifespan.

Dr. Bukata and the researchers at the University of Rochester are beginning a National Institute of Health placebo-controlled trial (Forteo vs Placebo) on individuals with pelvic fractures.

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2 Responses to “Osteoporosis Drug Speeds Fracture Healing”

  1. on 03 Dec 2010 at 3:38 pm Bruce M Chapman, DPM

    Are you aware of anyone who has used Forteo to accellerate bone consolidation in Stage 1-2 Charcot Joint fractures of diabetic feet?

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